Jonathan Silva
- Phone
314-935-8837 - Office
Whitaker Hall, Room 200G - Lab location
Whitaker Hall, Room 250 & 260
Google ScholarEducation
PhD, Washington University in St. Louis, 2008MS, Case Western Reserve University, 2004
BS, Johns Hopkins University, 2000
Expertise
Building patient-specific models of cardiac arrhythmia so that antiarrhythmic drug therapy can be prescribed more safely and more effectively for each patient
Focus
Cardiac Arrhythmia, Molecular Imaging, Engineered Cardiomyocytes, Computational Models, Extended Reality
Research
The Silva Lab studies how drugs and physiological state alter cardiac myocyte electrical activity to cause arrhythmia, combining patch clamp, fluorescent labels that report ion channel motion, stem cell-derived and native human cardiomyocytes, and computational models that link channel pharmacology to the ECG. Current projects address why women face higher risk of drug-induced arrhythmia, how amiodarone works, and how cancer drugs disrupt cardiac electrophysiology.
Biography
Prof. Silva joined WashU in 2012 with a Burroughs Wellcome Fund Career Award and holds a joint appointment in Computer Science & Engineering. His lab's holographic guidance software for catheter ablation is commercialized by SentiAR, Inc., where he is co-founder and CTO. He is also co-founder of Excera. He received the American Heart Association Established Investigator Award and has been elected as a senior member of the National Academy of Inventors.
Centers & Affiliations
