Piyoosh Sharma

Research

Piyoosh’s research focuses on developing protein- and peptide-based vaccine platforms for neurodegenerative diseases, with an emphasis on self-assembled nanofibers as adjuvant- and inflammation-free vaccine systems. His research combines protein engineering, immunology, and mass spectrometry-based proteomics to understand how these vaccine platforms interact with and modulate immune cells. A complementary focus of his work is the development of next-generation crosslinking mass spectrometry tools and workflows to map protein–protein interactions, characterize protein structure and molecular mechanisms, and investigate proteome-wide changes associated with antigen delivery and immune activation.

Biography

Piyoosh Sharma is a Research Assistant Professor in the Department of Biomedical Engineering at Washington University in St. Louis. Prior to joining Washington University, he was a postdoctoral fellow in the Department of Chemistry at Johns Hopkins University, Baltimore (2020-2025). He earned his Ph.D. in Pharmaceutical and Medicinal Chemistry from Indian Institute of Technology (IIT-BHU), India (2019).